Abstract
CAR T cells have shown dramatic effects against blood cancers, but they have had little impact on solid tumors. Researchers increased the effectiveness of CAR T-cell therapy in solid tumors by injecting the cells near the tumors. A phase I trial using this approach will begin early next year.
©2014 American Association for Cancer Research.
MeSH terms
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Animals
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Humans
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Immunotherapy
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Neoplasms / immunology*
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Neoplasms / therapy
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Receptors, Antigen, T-Cell / genetics*
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Receptors, Antigen, T-Cell / metabolism
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Recombinant Fusion Proteins / genetics*
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Recombinant Fusion Proteins / metabolism
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism*
Substances
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Receptors, Antigen, T-Cell
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Recombinant Fusion Proteins