Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example

Nikolaos P Daskalakis; Elisabeth B Binder

doi:10.1093/schbul/sbu189

Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example

Schizophr Bull. 2015 Mar;41(2):323-9. doi: 10.1093/schbul/sbu189. Epub 2015 Jan 14.

Authors

Nikolaos P Daskalakis¹, Elisabeth B Binder²

Affiliations

¹ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Mental Health Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY; nikolaos.daskalakis@mssm.edu.
² Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.

Abstract

Many studies have demonstrated that genotype (G) interacts with adverse life experiences (E) to produce individual differences in vulnerability and resilience to mental disorders, including schizophrenia. Genetic susceptibility to stress and the timing of the environmental exposure(s) are relevant for these interactions and represent common risk factors. We take the example of the FKBP5 gene to illustrate G × E interactions that predict pleiotropic psychiatric outcomes, including schizophrenia.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene-Environment Interaction*
Humans
Life Change Events*
Schizophrenia / etiology*
Schizophrenia / genetics*
Stress, Psychological / genetics*
Tacrolimus Binding Proteins / genetics*

Substances

Tacrolimus Binding Proteins
tacrolimus binding protein 5