Hiding in the dark: uncovering cancer drivers through image-guided genomics

Genome Biol. 2014 Dec 20;15(12):563. doi: 10.1186/s13059-014-0563-3.

Abstract

Genome analysis which takes into account tumor purity leads to discovery of PTEN as a tumor suppressor gene in high-grade serous ovarian cancer.

Publication types

  • Introductory Journal Article

MeSH terms

  • Biomarkers, Tumor / genetics
  • Cystadenocarcinoma, Serous / genetics*
  • Cystadenocarcinoma, Serous / pathology
  • Female
  • Genomics / methods*
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • PTEN Phosphohydrolase / genetics*
  • Prognosis

Substances

  • Biomarkers, Tumor
  • PTEN Phosphohydrolase
  • PTEN protein, human