A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol

Pediatrics. 2015 Mar;135(3):e753-5. doi: 10.1542/peds.2014-2673. Epub 2015 Feb 2.

Abstract

We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.

Keywords: respiratory depression; tramadol; ultrarapid CYP2D6.

Publication types

  • Case Reports

MeSH terms

  • Analgesics, Opioid / adverse effects
  • Analgesics, Opioid / therapeutic use
  • Child, Preschool
  • Cytochrome P-450 CYP2D6 / drug effects
  • Cytochrome P-450 CYP2D6 / genetics
  • Cytochrome P-450 CYP2D6 / metabolism*
  • Genotype
  • Humans
  • Male
  • Pain, Postoperative / drug therapy
  • Respiratory Insufficiency / enzymology
  • Respiratory Insufficiency / etiology*
  • Tonsillectomy
  • Tramadol / adverse effects*
  • Tramadol / therapeutic use

Substances

  • Analgesics, Opioid
  • Tramadol
  • Cytochrome P-450 CYP2D6