Abstract
The neu gene was first identified in rat tumors that had been induced by the carcinogen ethyl nitrosourea. The human homolog of neu, usually designated c-erbB-2, is located on chromosome 17, q21. It specifies a transmembrane receptor-like phosphoglycoprotein that is closely related to the EGFr (c-erbB-1). The ligand for c-erbB-2 is not known. A significant proportion of adenocarcinomas (especially of the breast, colon, and pancreas) have amplification and/or overexpression of c-erbB-2. The unique qualities associated with the subset of tumors that overexpress c-erbB-2 have not yet been firmly identified.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenocarcinoma / genetics
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Adenocarcinoma / metabolism
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Animals
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Antibodies, Monoclonal / biosynthesis
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Antibodies, Monoclonal / therapeutic use
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism
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Chromosome Mapping
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Chromosomes, Human, Pair 17
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Ethylnitrosourea
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Gene Amplification
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Humans
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Mice
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Neuroblastoma / chemically induced
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Neuroblastoma / genetics
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Neuroblastoma / therapy
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Oncogenes*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / immunology
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Rats
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Receptor, ErbB-2
Substances
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Antibodies, Monoclonal
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Proto-Oncogene Proteins
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Receptor, ErbB-2
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Ethylnitrosourea