Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma

X-P Chen; Y-J Dong; W-P Guo; W Wang; M-H Li; J Xu; J S Dumler; Y-Z Zhang

doi:10.1016/j.cmi.2014.09.008

Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma

Clin Microbiol Infect. 2015 Feb;21(2):182.e1-4. doi: 10.1016/j.cmi.2014.09.008. Epub 2014 Oct 29.

Authors

X-P Chen¹, Y-J Dong², W-P Guo¹, W Wang¹, M-H Li¹, J Xu¹, J S Dumler³, Y-Z Zhang⁴

Affiliations

¹ State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
² Department of Haematology, Peking University First Hospital, Beijing, China.
³ Departments of Pathology and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, USA.
⁴ State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: zhangyongzhen@icdc.cn.

PMID: 25658559
DOI: 10.1016/j.cmi.2014.09.008

Abstract

Wolbachia 16S rRNA and fbpA genes were twice detected over 5 days in the blood of a patient with high fever. The patient was given fluoroquinolones and the fever resolved. Four weeks later, he was diagnosed with non-Hodgkin's lymphoma and received R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) treatment resulting in complete remission. This is the first report of detection of Wolbachia genes from the blood of human patients with non-Hodgkin's lymphoma.

Keywords: Infection; Wolbachia agent; non-Hodgkin lymphoma.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Bacteremia / diagnosis*
Bacteremia / drug therapy
Cluster Analysis
DNA, Bacterial / blood*
DNA, Bacterial / chemistry
DNA, Bacterial / genetics
DNA, Ribosomal / chemistry
DNA, Ribosomal / genetics
Fluoroquinolones / therapeutic use
Gram-Negative Bacterial Infections / diagnosis*
Gram-Negative Bacterial Infections / drug therapy
Humans
Lymphoma, Non-Hodgkin / complications*
Male
Middle Aged
Molecular Sequence Data
Periplasmic Binding Proteins / genetics
Phylogeny
RNA, Ribosomal, 16S / genetics
Sequence Analysis, DNA
Treatment Outcome
Wolbachia / genetics*

Substances

DNA, Bacterial
DNA, Ribosomal
Fluoroquinolones
Periplasmic Binding Proteins
RNA, Ribosomal, 16S

Associated data

GENBANK/KF881044
GENBANK/KF881045