Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis

Qiang Cai; Jian Wu; Qu Cai; Er-Zhen Chen; Zhao-Yan Jiang

doi:10.1371/journal.pone.0117173

Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis

PLoS One. 2015 Feb 13;10(2):e0117173. doi: 10.1371/journal.pone.0117173. eCollection 2015.

Authors

Qiang Cai¹, Jian Wu¹, Qu Cai¹, Er-Zhen Chen², Zhao-Yan Jiang¹

Affiliations

¹ Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
² Department of Emergency, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Abstract

Background: The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.

Methods: Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).

Results: A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I2 = 93%).

Conclusions: Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde Dehydrogenase / genetics*
Aldehyde Dehydrogenase, Mitochondrial
Alleles*
Amino Acid Substitution
Case-Control Studies
Genetic Association Studies
Genetic Predisposition to Disease*
Humans
Neoplasms / genetics*
Odds Ratio
Polymorphism, Single Nucleotide*
Publication Bias

Substances

ALDH2 protein, human
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial

Grants and funding

This work was supported by National Natural Science Foundation (No. 81070367 and No. 81270537). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.