Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder--data from an association study of suicide attempts with clock genes

Joanna Pawlak; Monika Dmitrzak-Weglarz; Malgorzata Maciukiewicz; Monika Wilkosc; Anna Leszczynska-Rodziewicz; Dorota Zaremba; Pawel Kapelski; Joanna Hauser

doi:10.1016/j.psychres.2015.01.010

Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder--data from an association study of suicide attempts with clock genes

Psychiatry Res. 2015 Apr 30;226(2-3):517-20. doi: 10.1016/j.psychres.2015.01.010. Epub 2015 Jan 16.

Authors

Joanna Pawlak¹, Monika Dmitrzak-Weglarz², Malgorzata Maciukiewicz³, Monika Wilkosc⁴, Anna Leszczynska-Rodziewicz⁵, Dorota Zaremba², Pawel Kapelski⁵, Joanna Hauser²

Affiliations

¹ Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland. Electronic address: joanna.pawlak@gmail.com.
² Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland.
³ Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland; Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
⁴ Department of Individual Differences, Institute of Psychology, University of Bydgoszcz, Poland.
⁵ Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland.

PMID: 25724486
DOI: 10.1016/j.psychres.2015.01.010

Abstract

Suicidal behavior exhibits both circadian and annual rhythms. We were seeking an association between selected candidate clock genes and suicidal behavior in bipolar patients. The study included 441 bipolar patients and 422 controls and we genotyped 41 SNPs of the CLOCK, ARNTL, TIMELESS, PER3 genes. The main positive findings built up associations between selected polymorphisms and.

Keywords: Circadian rhythm; Clock genes; Suicide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ARNTL Transcription Factors / genetics
Adolescent
Adult
Aged
Aged, 80 and over
Bipolar Disorder / diagnosis
Bipolar Disorder / genetics*
Bipolar Disorder / psychology
CLOCK Proteins / genetics*
Circadian Rhythm / genetics*
Databases, Genetic
Female
Genetic Association Studies* / methods
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics
Suicidal Ideation
Suicide, Attempted* / psychology
Young Adult

Substances

ARNTL Transcription Factors
CLOCK Proteins