Circadian biology: rhythms leave their imprint

David W Ray

doi:10.1016/j.cub.2014.12.045

Circadian biology: rhythms leave their imprint

Curr Biol. 2015 Mar 2;25(5):R201-3. doi: 10.1016/j.cub.2014.12.045.

Author

David W Ray¹

Affiliation

¹ Faculty of Medical and Health Sciences, University of Manchester, Manchester, UK. Electronic address: david.w.ray@manchester.ac.uk.

PMID: 25734270
DOI: 10.1016/j.cub.2014.12.045

Abstract

A recent study has revealed that loss of neuronal expression of the paternally imprinted gene Ube3a in Angelman syndrome results in selective neuronal loss of robust circadian oscillations, with a resulting behavioural phenotype, and adipose tissue accumulation.

Publication types

Comment

MeSH terms

Angelman Syndrome / physiopathology*
Animals
Circadian Rhythm / physiology*
Genomic Imprinting / genetics*
Humans
Neurons / metabolism*
Ubiquitin-Protein Ligases / genetics*

Substances

Ubiquitin-Protein Ligases