Comparison of 131I-MIBG, 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT scans in a patient with extra adrenal paraganglioma associated with SDH-B gene mutation

Clin Nucl Med. 2015 May;40(5):439-41. doi: 10.1097/RLU.0000000000000751.

Abstract

Paragangliomas (PGLs) due to succinate dehydrogenase subunit B (SDH-B) mutation can be aggressive. A 40-year-old woman with normetanephrine-secreting, extra-adrenal, abdominal PGL due to SDH-B genetic mutation underwent surgical excision of primary, followed by whole-body I-MIBG scan after 6 months, which showed no abnormality. However, Ga-DOTANOC and F-FDG PET/CT scans showed primary site recurrence, hepatic and skeletal metastasis, with latter scan revealing more lesions. We suggest that F-FDG PET should be done in all patients with PGL due to SDH-B mutations, as it may show additional unsuspected lesions that may be missed by other tracers.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • 3-Iodobenzylguanidine*
  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Gland Neoplasms / genetics
  • Adult
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Multimodal Imaging
  • Mutation
  • Organometallic Compounds*
  • Paraganglioma / diagnostic imaging*
  • Paraganglioma / genetics
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Succinate Dehydrogenase / genetics
  • Tomography, X-Ray Computed

Substances

  • 68Ga-DOTANOC
  • Organometallic Compounds
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • 3-Iodobenzylguanidine
  • SDHB protein, human
  • Succinate Dehydrogenase