Mirror-image gastroschisis in monochorionic female twins

Toni Kasole Lubala; Sébastien Mbuyi-Musanzayi; Nina Lubala; Oscar Numbi Luboya; Prosper Muenze Kalenga; Koenraad Devriendt; Prosper Lukusa-Tshilobo

doi:10.1016/j.ejmg.2015.03.001

Mirror-image gastroschisis in monochorionic female twins

Eur J Med Genet. 2015 Apr;58(4):266-9. doi: 10.1016/j.ejmg.2015.03.001. Epub 2015 Mar 14.

Authors

Toni Kasole Lubala¹, Sébastien Mbuyi-Musanzayi², Nina Lubala³, Oscar Numbi Luboya¹, Prosper Muenze Kalenga⁴, Koenraad Devriendt⁵, Prosper Lukusa-Tshilobo⁶

Affiliations

¹ Department of Pediatrics, University Hospital, University of Lubumbashi, P.O. 1825, Lubumbashi, Democratic Republic of the Congo.
² Department of Surgery, University Hospital, University of Lubumbashi, P.O. 1825, Lubumbashi, Democratic Republic of the Congo.
³ Department of Ophthalmology, University Hospital, University of Lubumbashi, P.O. 1825, Lubumbashi, Democratic Republic of the Congo.
⁴ Department of Gynecology and Obstetrics, University Hospital, University of Lubumbashi, P.O. 1825, Lubumbashi, Democratic Republic of the Congo.
⁵ Center for Human Genetics, University Hospitals, KU Leuven, P.O. Box 602, 3000 Leuven, Belgium. Electronic address: Koenraad.devriendt@uzleuven.be.
⁶ Center for Human Genetics, University Hospitals, KU Leuven, P.O. Box 602, 3000 Leuven, Belgium; Department of Pediatrics, University Hospitals, University of Kinshasa, P.O. Box 123, Kin XI, Kinshasa, Democratic Republic of the Congo.

PMID: 25782636
DOI: 10.1016/j.ejmg.2015.03.001

Abstract

We report a case of "mirror-image" gastroschisis in female monochorionic twins. One of the twins presents a right-sided gastroschisis, the other a left-sided gastroschisis. Both twins have anteriorly placed anus and sacral dimple. To the best of our knowledge, this represents the first case of mirror image or discordant left and right gastroschisis in monochorionic twins reported in the literature. This observation may shed further light on the pathogenesis of gastroschisis.

Keywords: Gastroschisis; Left; Monochorionic twins; Right; Sacral dimples.

Publication types

Case Reports

MeSH terms

Diseases in Twins / genetics*
Female
Gastroschisis / genetics*
Humans
Infant, Newborn
Twins, Monozygotic / genetics*