A trojan horse for human immunodeficiency virus

Silvia Catuogno; Carla Lucia Esposito; Vittorio de Franciscis

doi:10.1016/j.chembiol.2015.03.002

A trojan horse for human immunodeficiency virus

Chem Biol. 2015 Mar 19;22(3):313-4. doi: 10.1016/j.chembiol.2015.03.002.

Authors

Silvia Catuogno¹, Carla Lucia Esposito¹, Vittorio de Franciscis²

Affiliations

¹ Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, 80145 Naples, Italy.
² Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, 80145 Naples, Italy. Electronic address: defranci@unina.it.

PMID: 25794434
DOI: 10.1016/j.chembiol.2015.03.002

Abstract

In this issue of Chemistry & Biology, Zhou et al. demonstrate the possibility of effective multiple targeting of HIV infection by using a multifunctional molecule in which an anti-CCR5 receptor aptamer (G-3) is conjugated to an anti-TNPO3 siRNA.

Publication types

Comment

MeSH terms

Aptamers, Nucleotide / administration & dosage*
HIV Infections / drug therapy*
HIV-1 / drug effects*
Humans
Macrophages / drug effects*
Receptors, CCR5 / genetics*
SELEX Aptamer Technique / methods*

Substances

Aptamers, Nucleotide
Receptors, CCR5