Genetic association analyses of neuregulin 1 gene polymorphism with endopheontype for sociality of Korean autism spectrum disorders family

Hee Jeong Yoo; Ran-Sook Woo; Soo-Churl Cho; Boong-Nyun Kim; Jae-Won Kim; Min-Sup Shin; Tae-Won Park; Jung-Woo Son; Un-Sun Chung; Subin Park; Mira Park; Soon Ae Kim

doi:10.1016/j.psychres.2015.03.015

Genetic association analyses of neuregulin 1 gene polymorphism with endopheontype for sociality of Korean autism spectrum disorders family

Psychiatry Res. 2015 Jun 30;227(2-3):366-8. doi: 10.1016/j.psychres.2015.03.015. Epub 2015 Mar 23.

Authors

Hee Jeong Yoo¹, Ran-Sook Woo², Soo-Churl Cho³, Boong-Nyun Kim³, Jae-Won Kim³, Min-Sup Shin³, Tae-Won Park⁴, Jung-Woo Son⁵, Un-Sun Chung⁶, Subin Park³, Mira Park⁷, Soon Ae Kim⁸

Affiliations

¹ Department of Anatomy and Neuroscience, College of Medicine, Eulji University, Daejeon, Korea.
² Department of Neuropsychiatry, Seoul National University Bungdang Hospital, Seongnam, Korea.
³ Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
⁴ Department of Psychiatry, Chonbuk National University Hospital, Jeonju, Korea.
⁵ Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea.
⁶ Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea.
⁷ Department of Preventive Medicine, School of medicine, Eulji University, Daejeon, Korea.
⁸ Department of Pharmacology, School of Medicine, Eulji University, 771-77 Gyerhong-ro, Daejeon 301-746, Korea. Electronic address: sakim@eulji.ac.kr.

PMID: 25858800
DOI: 10.1016/j.psychres.2015.03.015

Abstract

To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.

Keywords: Autism spectrum disorder; Family-based association study; Neuregulin 1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics*
Child
Child Development Disorders, Pervasive / ethnology
Child Development Disorders, Pervasive / genetics*
Ethnicity / genetics
Female
Genetic Testing
Genome-Wide Association Study
Humans
Male
Neuregulin-1 / genetics*
Phenotype
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Republic of Korea
Schizophrenia / ethnology
Schizophrenia / genetics*

Substances

Neuregulin-1