When one mutation is all it takes

Mel Greaves

doi:10.1016/j.ccell.2015.03.016

When one mutation is all it takes

Cancer Cell. 2015 Apr 13;27(4):433-4. doi: 10.1016/j.ccell.2015.03.016.

Author

Mel Greaves¹

Affiliation

¹ Centre for Evolution and Cancer, The Institute of Cancer Research, London, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. Electronic address: mel.greaves@icr.ac.uk.

PMID: 25873168
DOI: 10.1016/j.ccell.2015.03.016

Abstract

In a recent issue of Nature Genetics, Andersson and colleagues report that MLL fusion alone may be sufficient to spawn an aggressive leukemia in infants. Some other pediatric cancers may share a similar, single, "big-hit" origin, possibly reflecting a critical developmental window of stem cell vulnerability.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Mutation*
Myeloid-Lymphoid Leukemia Protein / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*

Substances

Myeloid-Lymphoid Leukemia Protein

Grants and funding

105104/Wellcome Trust/United Kingdom