Atypical fibrodysplasia ossificans progressiva diagnosed by whole-exome sequencing

Am J Med Genet A. 2015 Jun;167(6):1337-41. doi: 10.1002/ajmg.a.36969. Epub 2015 Apr 21.

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification of connective tissue that begins during the first decade of life. Our patient presented with intrauterine growth retardation, respiratory distress, neonatal onset soft tissue masses, bilateral hallux valgus, and congenital anomalies of the thyroid and uterus. She was initially diagnosed with atypical infantile myofibromatosis based on clinical and pathological findings. She underwent whole-exome sequencing (WES) as part of the FORGE study to identify the gene for infantile myofibromatosis; however a de novo dominant mutation in ACVR1 (NM_001105.4:c.617G>A) revised the diagnosis to FOP. This patient highlights the utility of WES as an early diagnostic tool in the investigation of patients with unusual presentations of rare diseases, thereby providing clinicians with accurate molecular diagnoses and the opportunity to tailor clinical management to improve patient care.

Keywords: fibrodysplasia ossificans progressiva; hallux valgus; heterotopic ossification; whole exome sequencing.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activin Receptors, Type I / genetics*
  • Child, Preschool
  • Exome
  • Fatal Outcome
  • Female
  • Fetal Growth Retardation / diagnosis
  • Fetal Growth Retardation / genetics*
  • Fetal Growth Retardation / pathology
  • Hallux Valgus / diagnosis
  • Hallux Valgus / genetics*
  • Hallux Valgus / pathology
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Mutation*
  • Myositis Ossificans / diagnosis
  • Myositis Ossificans / genetics*
  • Myositis Ossificans / pathology
  • Respiratory Distress Syndrome, Newborn / diagnosis
  • Respiratory Distress Syndrome, Newborn / genetics*
  • Respiratory Distress Syndrome, Newborn / pathology
  • Thyroid Gland / abnormalities
  • Uterus / abnormalities

Substances

  • ACVR1 protein, human
  • Activin Receptors, Type I