Association of copeptin and cortisol in newly diagnosed multiple sclerosis patients

J Neuroimmunol. 2015 May 15:282:21-4. doi: 10.1016/j.jneuroim.2015.03.011. Epub 2015 Mar 11.

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Obesity may increase the risk of developing MS. The aim of this study was to evaluate copeptin and cortisol plasma levels in newly diagnosed untreated MS patients and to determine whether copeptin and cortisol are related to the patients' clinical statuses. We report that copeptin and cortisol were higher in overweight/obese MS patients. Positive correlations were observed between the two parameters. We conclude that alterations of copeptin and cortisol levels in multiple sclerosis patients may be related to adiposity. An increase in cortisol may also be associated with copeptin secretion.

Keywords: Adiposity; Copeptin; Cortisol; Multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity / physiology
  • Adolescent
  • Adult
  • Anthropometry
  • Disability Evaluation
  • Female
  • Glycopeptides / blood*
  • Humans
  • Hydrocortisone / blood*
  • Male
  • Middle Aged
  • Severity of Illness Index
  • Statistics as Topic
  • Statistics, Nonparametric
  • Steatocystoma Multiplex / blood*
  • Young Adult

Substances

  • Glycopeptides
  • copeptins
  • Hydrocortisone