Behavioral effects of neonatal lesions on the cerebellar system

Int J Dev Neurosci. 2015 Jun:43:58-65. doi: 10.1016/j.ijdevneu.2015.04.007. Epub 2015 Apr 20.

Abstract

Several rodent models with spontaneous mutations causing cerebellar pathology are impaired in motor functions during the neonatal period, including Grid2(Lc), Rora(sg), Dab1(scm), Girk2(Wv), Lmx1a(dr-sst), Myo5a(dn), Inpp4a(wbl), and Cacna1a(rol) mice as well as shaker and dystonic rats. Deficits are also evident in murine null mutants such as Zic1, Fgfr1/FgFr2, and Xpa/Ercc8. Behavioral deficits are time-dependent following X-irradiated- or aspiration-induced lesions of the cerebellum in rats. In addition, motor functions are deficient after lesions in cerebellar-related pathways. As in animal subjects, sensorimotor disturbances have been described in children with cerebellar lesions. These results underline the importance of the cerebellum and its connections in the development of motor functions.

Keywords: Body righting; Cerebellar mutants; Cerebellum; Granule cells; Motor coordination; Paw-clasping; Purkinje cells; Rotorod; SHIRPA; Stationary beam; Wire suspension; X-Irradiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Aspirations, Psychological
  • Cerebellar Diseases* / complications
  • Cerebellar Diseases* / etiology
  • Cerebellar Diseases* / genetics
  • Cerebellum / pathology
  • Developmental Disabilities / etiology*
  • Mental Disorders / etiology*
  • Mice
  • Mice, Mutant Strains
  • Motor Activity / genetics*
  • Mutation / genetics
  • Neurons / pathology
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics
  • Radiation Injuries / complications
  • Rats
  • Rats, Mutant Strains
  • Time Factors

Substances

  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Rora protein, mouse