Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology

Pharmacol Res. 2015 Sep:99:11-5. doi: 10.1016/j.phrs.2015.05.001. Epub 2015 May 12.

Abstract

Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multi-function of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis.

Keywords: Anti-metastasis; Calumenin; Cell migration; Fibulin-1.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / pharmacology*
  • Calcium-Binding Proteins / physiology
  • Cell Adhesion / drug effects
  • Cell Adhesion / physiology
  • Cell Movement / drug effects
  • Cell Movement / physiology
  • Gene Expression
  • Humans
  • Models, Biological
  • Neoplasm Metastasis / physiopathology
  • Neoplasm Metastasis / prevention & control*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / physiopathology

Substances

  • Antineoplastic Agents
  • CALU protein, human
  • Calcium-Binding Proteins
  • fibulin