The NLRP3-CASP1 Inflammasome Induces Glucocorticoid Resistance in ALL

Cancer Discov. 2015 Jul;5(7):OF18. doi: 10.1158/2159-8290.CD-RW2015-090. Epub 2015 May 14.

Abstract

Overexpression of CASP1 and its activator NLRP3 confers glucocorticoid resistance in ALL.

MeSH terms

  • Carrier Proteins / genetics*
  • Caspase 1 / genetics*
  • Drug Resistance, Neoplasm*
  • Gene Expression Regulation, Neoplastic
  • Glucocorticoids / therapeutic use
  • Humans
  • Inflammasomes / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Receptors, Glucocorticoid / metabolism

Substances

  • Carrier Proteins
  • Glucocorticoids
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Receptors, Glucocorticoid
  • Caspase 1