MYC Regulates Expression of Pre-mRNA Splicing Machinery in Lymphoma

Cancer Discov. 2015 Jul;5(7):692. doi: 10.1158/2159-8290.CD-RW2015-093. Epub 2015 May 21.

Abstract

MYC-mediated maintenance of proper mRNA splicing is essential for lymphomagenesis.

MeSH terms

  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lymphoma / genetics
  • Lymphoma / pathology*
  • Proto-Oncogene Proteins c-myc / genetics*
  • RNA Splicing*
  • snRNP Core Proteins / metabolism

Substances

  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • snRNP Core Proteins