Screening for Barrett's Esophagus

Milli Gupta; Prasad G Iyer

doi:10.1016/j.gtc.2015.02.003

Screening for Barrett's Esophagus

Gastroenterol Clin North Am. 2015 Jun;44(2):265-83. doi: 10.1016/j.gtc.2015.02.003.

Authors

Milli Gupta¹, Prasad G Iyer²

Affiliations

¹ Division of Gastroenterology and Hepatology, University of Calgary, 2500 University Dr NW, Calgary, Alberta T2N 1N4, Canada.
² Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: iyer.prasad@mayo.edu.

PMID: 26021194
DOI: 10.1016/j.gtc.2015.02.003

Abstract

There is substantial interest in identifying patients with premalignant conditions such as Barrett's esophagus (BE), to improve outcomes of subjects with esophageal adenocarcinoma. However, there is limited consensus on the rationale for screening, the appropriate target population, and optimal screening modality. Recent progress in the development and validation of minimally invasive tools for BE screening has reinvigorated interest in BE screening. BE risk scores combining clinical, anthropometric, and laboratory variables are being developed that may allow more precise targeting of screening to high-risk individuals. This article reviews and summarizes data on recent progress and challenges in screening for BE.

Keywords: Barrett’s esophagus; Esophageal adenocarcinoma; Screening.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Barrett Esophagus / diagnosis*
Early Detection of Cancer / instrumentation
Early Detection of Cancer / methods*
Esophagoscopy / instrumentation
Esophagoscopy / methods*
Humans
Population Surveillance / methods
Precancerous Conditions / diagnosis*
Risk Assessment