Abstract
Mantle cell lymphoma is one of the B-cell lymphomas. The concurrent presentation of mantle cell lymphoma with large granular lymphocytic leukemia simultaneously has never been reported. In this case we present an old man with concomitant mantle cell lymphoma and large granular lymphocytic leukemia diagnosed by the morphology of the bone marrow aspiration, immunophenotyping of the peripheral blood by flow cytometry detecting the increased CD3+CD4-CD8+ cells, immunohistochemical studies of lymph node showed cyclinD1+, chromosome analysis by fluorescence in situ hybridization (FISH) showed t(11,14), positive results of IGH and TCR rearrangement studies. The patient discharged from the hospital voluntarily and lost the follow-up. A brief discussion is also presented.
Keywords:
Mantle cell lymphoma; concurrent; large granular lymphocytic leukemia.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aged
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics
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Bone Marrow Examination
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 14
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Flow Cytometry
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Gene Rearrangement
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Gene Rearrangement, T-Lymphocyte
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Genes, Immunoglobulin Heavy Chain
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Genetic Predisposition to Disease
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Humans
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Immunohistochemistry
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Immunophenotyping
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In Situ Hybridization, Fluorescence
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Leukemia, Large Granular Lymphocytic / genetics
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Leukemia, Large Granular Lymphocytic / immunology
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Leukemia, Large Granular Lymphocytic / pathology*
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Lymphoma, Mantle-Cell / genetics
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Lymphoma, Mantle-Cell / immunology
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Lymphoma, Mantle-Cell / pathology*
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Male
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / immunology
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Neoplasms, Multiple Primary / pathology*
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Phenotype
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Translocation, Genetic