Interactions between childhood maltreatment and brain-derived neurotrophic factor and serotonin transporter polymorphisms on depression symptoms

Psychiatry Res. 2015 Sep 30;229(1-2):609-12. doi: 10.1016/j.psychres.2015.04.040. Epub 2015 May 29.

Abstract

This study represents the first replication of the BDNF Val66Met ⁎ 5-HTTLPR ⁎ childhood maltreatment effect on self-reported depression symptoms using a rigorous maltreatment interview. Participants included a community sample of 339 adolescents/young adults (age 12-33; 265 female). In the context of childhood neglect, among BDNF Met-carriers, s-allele carriers of 5-HTTLPR reported significantly higher depression than l/l homozygotes, whereas a differential relation of 5-HTTLPR genotype to depression was not seen among BDNF Val/Val homozygotes.

Keywords: BDNF gene; Depression; Serotonin transporter gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain-Derived Neurotrophic Factor / genetics*
  • Child Abuse / psychology*
  • Depression / genetics*
  • Depression / psychology*
  • Epistasis, Genetic / genetics*
  • Female
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic / genetics
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Young Adult

Substances

  • Brain-Derived Neurotrophic Factor
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • BDNF protein, human