The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population

PLoS One. 2015 Jun 16;10(6):e0130377. doi: 10.1371/journal.pone.0130377. eCollection 2015.

Abstract

Background: Aberrant alternative splicing included alterations in components of the mRNA splicing machinery often occurred in colon cancer. However, the role of SF3A1, one key component of the mRNA splicing machinery, on colorectal cancer (CRC) risk was still not elucidated.

Method and findings: We performed a hospital-based case-control study containing 801 CRC patients and 817 cancer-free controls to examine the association between SF3A1 polymorphisms and CRC risk in a Chinese population. Four candidate SNPs (rs10376, rs5753073, rs2839998 and rs2074733) were selected based on bioinformatics analysis and previous findings. The results showed no significant associations between these SNPs and CRC risk (P > 0.05). Besides, the stratified analysis based on the smoking and alcohol use status obtained no statistically significant results.

Conclusion: Our study was the first one to investigate the association between SF3A1 polymorphisms and CRC risk. The results suggested these four SNPs in SF3A1 were not associated with CRC risk in a Chinese population, however, further more studies are needed to confirm our findings.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking / genetics
  • Case-Control Studies
  • China / epidemiology
  • Colorectal Neoplasms / epidemiology*
  • Colorectal Neoplasms / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • RNA Splicing / genetics*
  • RNA Splicing Factors
  • Ribonucleoprotein, U2 Small Nuclear / genetics*
  • Risk Factors
  • Smoking / genetics

Substances

  • RNA Splicing Factors
  • Ribonucleoprotein, U2 Small Nuclear
  • SF3A1 protein, human

Grants and funding

This work was supported by the National Natural Science Foundation of China (Grant No. 31172395), the Key Technologies Research and Development Program of China (Grant No. 2013BAI12B01-3) and the Health and Family Planning Commission of Hubei Province of China (Grant No. WJ-2015MB039). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.