BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma

Cancer Genet. 2015 Jul-Aug;208(7-8):404-7. doi: 10.1016/j.cancergen.2015.04.007. Epub 2015 Apr 28.

Abstract

The BCR-PDGFRA fusion is a very rare event. To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. All cases except one had eosinophilia. We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. Radiology showed splenomegaly and extensive lymph node involvement. The patient rapidly achieved complete remission with treatment protocol for Philadelphia chromosome-negative acute lymphoblastic leukemia.

Keywords: BCR gene; BCR-PDGFRA fusion; PDGFRA gene; T-ALL; t(4;22)(q12;q11.2).

Publication types

  • Case Reports

MeSH terms

  • Chromosome Banding
  • Chromosomes, Human, Pair 22 / genetics
  • Chromosomes, Human, Pair 4 / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotype
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Proto-Oncogene Proteins c-bcr / genetics*
  • Receptor, Platelet-Derived Growth Factor alpha / genetics*
  • Translocation, Genetic

Substances

  • Oncogene Proteins, Fusion
  • Receptor, Platelet-Derived Growth Factor alpha
  • BCR protein, human
  • Proto-Oncogene Proteins c-bcr