Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB

Yujin Sun; Hoe Suk Kim; Phei Er Saw; Sangyong Jon; Woo Kyung Moon

doi:10.1002/adhm.201500190

Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB

Adv Healthc Mater. 2015 Aug 5;4(11):1675-80. doi: 10.1002/adhm.201500190. Epub 2015 Jun 11.

Authors

Yujin Sun^{1

2}, Hoe Suk Kim¹, Phei Er Saw³, Sangyong Jon³, Woo Kyung Moon¹

Affiliations

¹ Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.
² Department of Radiology, Yanbian University Hospital, 1327 JuZi Street, Yanji City, JiLin Province, 133000, China.
³ Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, South Korea.

PMID: 26097122
DOI: 10.1002/adhm.201500190

Abstract

Targeted therapy for breast cancer stem cell (BCSC): A novel liposomal system (APTEDB -LS-siRNA(EDB) ) that enables simultaneous targeting and knockdown of extra domain B of fibronectin (EDB-FN) shows potent therapeutic efficacy in the BCSC-derived tumors in vivo.

Keywords: RNA; aptides; breast cancer; fibronectin; liposomes; stem cells; targeted cancer therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Breast Neoplasms / metabolism
Breast Neoplasms / pathology
Breast Neoplasms / therapy
Cell Line, Tumor
Cell Proliferation
Female
Fibronectins / antagonists & inhibitors
Fibronectins / genetics
Fibronectins / metabolism*
Humans
Liposomes / chemistry*
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplastic Stem Cells / cytology
Neoplastic Stem Cells / metabolism*
RNA Interference
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism*
RNA, Small Interfering / therapeutic use
Transplantation, Heterologous

Substances

Fibronectins
Liposomes
RNA, Small Interfering