Abstract
Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.
Keywords:
HDAC1; MORC2; cell proliferation; gastric cancer; p21.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Proliferation / genetics
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Cyclin-Dependent Kinase Inhibitor p21 / antagonists & inhibitors
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Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis*
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DNA-Binding Proteins / metabolism
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Down-Regulation
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Histone Deacetylase 1 / metabolism*
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Humans
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Promoter Regions, Genetic / genetics
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RNA Interference
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RNA, Messenger / genetics
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RNA, Small Interfering
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Stomach Neoplasms / pathology*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic / genetics
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Tumor Cells, Cultured
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Tumor Suppressor Protein p53 / metabolism*
Substances
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CDKN1A protein, human
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Cyclin-Dependent Kinase Inhibitor p21
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DNA-Binding Proteins
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MORC2 protein, human
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RNA, Messenger
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RNA, Small Interfering
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Transcription Factors
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Tumor Suppressor Protein p53
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HDAC1 protein, human
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Histone Deacetylase 1