Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment

Cytokine Growth Factor Rev. 2015 Aug;26(4):389-403. doi: 10.1016/j.cytogfr.2015.06.001. Epub 2015 Jun 20.

Abstract

Recently it was discovered that a transient activation of transcription factor NF-κB can give cells properties essential for invasiveness and cancer initiating potential. In contrast, most oncogenes to date were characterized on the basis of mutations or by their constitutive overexpression. Study of NF-κB actually leads to a far more dynamic perspective on cancer: tumors caused by diverse oncogenes apparently evolve into cancer after loss of feedback regulation for NF-κB. This event alters the cellular phenotype and the expression of hormonal mediators, modifying signals between diverse cell types in a tissue. The result is a disruption of stem cell hierarchy in the tissue, and pervasive changes in the microenvironment and immune response to the malignant cells.

Keywords: Cancer; Homeostasis; Immunity; Inflammation; Nuclear Factor kappa B.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Carcinogenesis / metabolism
  • Humans
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*
  • Tumor Microenvironment / physiology*

Substances

  • NF-kappa B