Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Psychiatry Res. 2015 Aug 30;228(3):945-9. doi: 10.1016/j.psychres.2015.06.013. Epub 2015 Jun 26.

Abstract

A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.

Keywords: Pathway analysis; Pruning; Schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / genetics*
  • Female
  • Gene Regulatory Networks / genetics*
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genetic Variation / genetics
  • Humans
  • Inflammation / diagnosis
  • Inflammation / genetics
  • Internationality
  • Male
  • Middle Aged
  • Neuronal Plasticity / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Schizophrenia / diagnosis
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*