Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese

Psychiatry Res. 2015 Oct 30;229(3):1043-6. doi: 10.1016/j.psychres.2015.06.012. Epub 2015 Jun 25.

Abstract

Recently, the novel SNP rs12704290 in GRM3 was identified in a genome-wide association study on schizophrenia susceptibility. Our study was to investigate the association of 29 selected SNPs (including rs12704290) with schizophrenia and to evaluate any possible relationship between them and cognition related to schizophrenia. The SNPs were analyzed in 1115 unrelated schizophrenic patients and 2289 healthy controls. The results showed significant associations between these SNPs and schizophrenia as well as with changes in cognition.

Keywords: Cognitive function; Glutamate receptor; Schizophrenia susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics*
  • Case-Control Studies
  • Cognition*
  • Female
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Protein Isoforms / genetics
  • Receptors, Metabotropic Glutamate / genetics*
  • Schizophrenia / genetics*

Substances

  • Protein Isoforms
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor 3