Meta-analysis of dopamine receptor D1 rs4532 polymorphism and susceptibility to antipsychotic treatment response

Psychiatry Res. 2015 Sep 30;229(1-2):586-8. doi: 10.1016/j.psychres.2015.07.054. Epub 2015 Jul 21.

Abstract

Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. Thus, we have conducted a systematic review followed by a meta-analysis. Our results indicated no association between DRD1 rs4532 polymorphism and overall antipsychotic response or clozapine monotherapy response.

Keywords: Clozapine; Pharmacogenetics; Pharmacogenomics.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Antipsychotic Agents / therapeutic use*
  • Clozapine / therapeutic use
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Dopamine D1 / genetics*
  • Schizophrenia / drug therapy*
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • Receptors, Dopamine D1
  • Clozapine