Abstract
Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. Thus, we have conducted a systematic review followed by a meta-analysis. Our results indicated no association between DRD1 rs4532 polymorphism and overall antipsychotic response or clozapine monotherapy response.
Keywords:
Clozapine; Pharmacogenetics; Pharmacogenomics.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Meta-Analysis
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Research Support, Non-U.S. Gov't
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Systematic Review
MeSH terms
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Antipsychotic Agents / therapeutic use*
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Clozapine / therapeutic use
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Female
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Genetic Predisposition to Disease / epidemiology
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Genetic Predisposition to Disease / genetics*
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Humans
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Male
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Polymorphism, Single Nucleotide / genetics*
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Receptors, Dopamine D1 / genetics*
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Schizophrenia / drug therapy*
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Schizophrenia / epidemiology
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Schizophrenia / genetics*
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Treatment Outcome
Substances
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Antipsychotic Agents
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Receptors, Dopamine D1
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Clozapine