Abstract
Mixed focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) within a single tumor mass is rarely reported, and most of these cases are examples of tumors with features intermediate between FNH and HCA. Although a few reported cases are probably examples of true mixed tumors, none was evaluated immunohistochemically or confirmed by molecular analysis. We report a mixed FNH and HCA arising in a woman with several HNF1A-inactivated adenomas. Our case is the first case of mixed FNH and HNF1A-inactivated HCA documented by immunohistochemistry.
MeSH terms
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Adenoma, Liver Cell / chemistry
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Adenoma, Liver Cell / genetics*
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Adenoma, Liver Cell / pathology*
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Adenoma, Liver Cell / surgery
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Adult
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics*
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Biopsy
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Female
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Focal Nodular Hyperplasia / pathology*
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Focal Nodular Hyperplasia / surgery
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Gene Silencing*
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Genetic Predisposition to Disease
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Hepatectomy
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Hepatocyte Nuclear Factor 1-alpha / genetics*
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Humans
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Immunohistochemistry
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Liver Neoplasms / chemistry
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Liver Neoplasms / genetics*
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Liver Neoplasms / pathology*
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Liver Neoplasms / surgery
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Neoplasms, Complex and Mixed / chemistry
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Neoplasms, Complex and Mixed / genetics*
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Neoplasms, Complex and Mixed / pathology*
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Neoplasms, Complex and Mixed / surgery
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Phenotype
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Predictive Value of Tests
Substances
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Biomarkers, Tumor
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HNF1A protein, human
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Hepatocyte Nuclear Factor 1-alpha