Simultaneous occurrence of focal nodular hyperplasia and HNF1A-inactivated hepatocellular adenoma: a collision tumor simulating a composite FNH-HCA

Am J Surg Pathol. 2015 Sep;39(9):1296-300. doi: 10.1097/PAS.0000000000000477.

Abstract

Mixed focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) within a single tumor mass is rarely reported, and most of these cases are examples of tumors with features intermediate between FNH and HCA. Although a few reported cases are probably examples of true mixed tumors, none was evaluated immunohistochemically or confirmed by molecular analysis. We report a mixed FNH and HCA arising in a woman with several HNF1A-inactivated adenomas. Our case is the first case of mixed FNH and HNF1A-inactivated HCA documented by immunohistochemistry.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Liver Cell / chemistry
  • Adenoma, Liver Cell / genetics*
  • Adenoma, Liver Cell / pathology*
  • Adenoma, Liver Cell / surgery
  • Adult
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics*
  • Biopsy
  • Female
  • Focal Nodular Hyperplasia / pathology*
  • Focal Nodular Hyperplasia / surgery
  • Gene Silencing*
  • Genetic Predisposition to Disease
  • Hepatectomy
  • Hepatocyte Nuclear Factor 1-alpha / genetics*
  • Humans
  • Immunohistochemistry
  • Liver Neoplasms / chemistry
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / surgery
  • Neoplasms, Complex and Mixed / chemistry
  • Neoplasms, Complex and Mixed / genetics*
  • Neoplasms, Complex and Mixed / pathology*
  • Neoplasms, Complex and Mixed / surgery
  • Phenotype
  • Predictive Value of Tests

Substances

  • Biomarkers, Tumor
  • HNF1A protein, human
  • Hepatocyte Nuclear Factor 1-alpha