Progesterone receptor-estrogen receptor crosstalk: a novel insight

Christoforos Thomas; Jan-Åke Gustafsson

doi:10.1016/j.tem.2015.08.002

Progesterone receptor-estrogen receptor crosstalk: a novel insight

Trends Endocrinol Metab. 2015 Sep;26(9):453-4. doi: 10.1016/j.tem.2015.08.002. Epub 2015 Aug 12.

Authors

Christoforos Thomas¹, Jan-Åke Gustafsson²

Affiliations

¹ Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, Texas 77204, USA. Electronic address: chthomas@uh.edu.
² Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, Texas 77204, USA. Electronic address: jgustafsson@uh.edu.

PMID: 26277479
DOI: 10.1016/j.tem.2015.08.002

Abstract

Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.

Publication types

Review

MeSH terms

Breast Neoplasms / genetics*
Estrogen Receptor alpha / genetics
Female
Humans
Receptor Cross-Talk*
Receptors, Estrogen / genetics*
Receptors, Progesterone / genetics*

Substances

ESR1 protein, human
Estrogen Receptor alpha
Receptors, Estrogen
Receptors, Progesterone