Abstract
Epstein-Barr virus (EBV) was first discovered 50 years ago as an oncogenic gamma-1 herpesvirus and infects more than 90% of the worldwide adult population. Nasopharyngeal carcinoma (NPC) poses a serious health problem in southern China and is one of the most common cancers among the Chinese. There is now strong evidence supporting a role for EBV in the pathogenesis of NPC. Latent membrane protein 1 (LMP1), a primary oncoprotein encoded by EBV, alters several functional and oncogenic properties, including transformation, cell death and survival in epithelial cells in NPC. LMP1 may increase protein modification, such as phosphorylation, and initiate aberrant signalling via derailed activation of host adaptor molecules and transcription factors. Here, we summarise the novel features of different domains of LMP1 and several new LMP1-mediated signalling pathways in NPC. When then focus on the potential roles of LMP1 in cancer stem cells, metabolism reprogramming, epigenetic modifications and therapy strategies in NPC.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Carcinoma
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Epstein-Barr Virus Infections / genetics*
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Epstein-Barr Virus Infections / metabolism
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Epstein-Barr Virus Infections / pathology
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Epstein-Barr Virus Infections / virology
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ErbB Receptors / genetics
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ErbB Receptors / metabolism
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Gene Expression Regulation, Viral*
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Herpesvirus 4, Human / genetics*
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Herpesvirus 4, Human / pathogenicity
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Host-Pathogen Interactions
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Humans
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Nasopharyngeal Carcinoma
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Nasopharyngeal Neoplasms / genetics*
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Nasopharyngeal Neoplasms / metabolism
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Nasopharyngeal Neoplasms / pathology
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Nasopharyngeal Neoplasms / virology
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Neoplastic Stem Cells / metabolism
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Neoplastic Stem Cells / pathology
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Neoplastic Stem Cells / virology
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Phosphorylation
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Protein Processing, Post-Translational
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Protein Structure, Tertiary
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Signal Transduction
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism
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Viral Matrix Proteins / chemistry
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Viral Matrix Proteins / genetics*
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Viral Matrix Proteins / metabolism
Substances
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EBV-associated membrane antigen, Epstein-Barr virus
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Tumor Suppressor Protein p53
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Viral Matrix Proteins
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EGFR protein, human
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ErbB Receptors