The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease

Tumour Biol. 2016 Jan;37(1):1271-8. doi: 10.1007/s13277-015-3914-0. Epub 2015 Aug 20.

Abstract

The aim of this study is to determine the prognostic value of tumor markers, as squamous cell carcinoma antigen (SCCAg) and cytokeratin-19 fragment (CYFRA 21.1) and interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), soluble tumor necrosis factor receptor I (sTNF RI), and sTNF RII in patients with squamous cell carcinoma of the cervix. The subjects of analysis were 138 patients with stage I-IVA according to the International Federation of Gynecology and Obstetrics (FIGO) classification. The collected research material comes from one oncology center. During the 10 years of follow-up, 56 relapses and 53 deaths were observed, and recurrent disease in early stage was confirmed in 45 % of patients. The pretreatment serum levels of SCCAg and CYFRA 21.1, and cytokines IL-6, VEGF, sTNF RI, and sTNF RII were determined in all patients. The probability of disease-free survival (DFS) and overall survival (OS) was evaluated using the log-rank test and the Cox regression model. Based on the ROC curve analysis for patients with recurrence, the largest area under the curve was demonstrated for SCCAg and IL-6 and for patients who died, for SCCAg and VEGF. Cox analysis demonstrated that independent prognostic factor for DFS was only SCCAg and for OS cytokine IL-6 and SCCAg, but in patients with early stage the prognostic value for DFS was VEGF, whereas IL-6 and CYFRA 21.1 for OS. Serum level of VEGF, CYFRA 21.1 and IL-6 before treatment in patients with early stage cervical cancer appears to be an important prognostic factor.

Keywords: CYFRA 21.1; Cervical cancer; IL6; SCCAg; VEGF.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Neoplasm / blood*
  • Area Under Curve
  • Carcinoma, Squamous Cell / blood
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / genetics
  • Female
  • Follow-Up Studies
  • Humans
  • Interleukin-6 / blood*
  • Keratin-19 / blood*
  • Middle Aged
  • Prognosis
  • Receptors, Tumor Necrosis Factor / blood*
  • Recurrence
  • Sensitivity and Specificity
  • Serpins / blood*
  • Uterine Cervical Neoplasms / blood
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / genetics
  • Vascular Endothelial Growth Factor A / blood*

Substances

  • Antigens, Neoplasm
  • IL6 protein, human
  • Interleukin-6
  • Keratin-19
  • Receptors, Tumor Necrosis Factor
  • Serpins
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • antigen CYFRA21.1
  • squamous cell carcinoma-related antigen