Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion

Oncotarget. 2015 Oct 20;6(32):33523-33. doi: 10.18632/oncotarget.5590.

Abstract

Golgi Protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC), however its role in HCC is not clear. We report that GP73 promotes cell invasion, the hallmark of malignancy, through the upregulation of matrix metalloproteinase-13 (MMP-13). GP73 enhances MMP-13 expression through cAMP responsive element binding protein (CREB)-mediated transcription activation. Levels of GP73 and MMP-13 are increased and positively correlated in human HCC tissues. Augmented MMP-13 potentiates HCC cell metastasis. Thus, the GP73-CREB-MMP-13 axis potentiates cancer cell invasion and may be a target for HCC treatment.

Keywords: GP73; hepatocellular carcinoma; invasion; matrix metalloproteinase-13.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / metabolism*
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology
  • Matrix Metalloproteinase 13 / genetics
  • Matrix Metalloproteinase 13 / metabolism*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Neoplasm Invasiveness

Substances

  • CREB1 protein, human
  • Cyclic AMP Response Element-Binding Protein
  • GOLM1 protein, human
  • Membrane Proteins
  • MMP13 protein, human
  • Matrix Metalloproteinase 13