Abstract
Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest in thyroid cancer cells. Moreover, SOSTDC1 over-expression suppressed the growth of tumor xenografts in nude mice. We also found that elevated SOSTDC1 led to inhibition of cyclin A2 and cyclin E2. Together,our results demonstrate that SOSTDC1 is down-regulated in thyroid cancer and might be a potential therapeutic target in the treatment of thyroid cancer.
Keywords:
SOSTDC1; cyclin A2; cyclin E2; proliferation; thyroid cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Apoptosis
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Blotting, Western
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Cell Cycle
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Cell Proliferation*
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Cyclin A2 / genetics*
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Cyclin A2 / metabolism
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Cyclins / genetics*
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Cyclins / metabolism
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Down-Regulation
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunoenzyme Techniques
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Intracellular Signaling Peptides and Proteins
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Middle Aged
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Neoplasm Staging
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Prognosis
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Proteins / genetics
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Proteins / metabolism*
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RNA, Messenger / genetics
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Real-Time Polymerase Chain Reaction
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Reverse Transcriptase Polymerase Chain Reaction
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / metabolism
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Thyroid Neoplasms / pathology*
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Tumor Cells, Cultured
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Xenograft Model Antitumor Assays
Substances
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Adaptor Proteins, Signal Transducing
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CCNA2 protein, human
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CCNE2 protein, human
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Cyclin A2
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Cyclins
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Intracellular Signaling Peptides and Proteins
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Proteins
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RNA, Messenger
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SOSTDC1 protein, human