Association of FCGR2A p.R131H and CCL2 c.-2518 A>G gene variants with thrombocytopenia in patients with dengue virus infection

Hum Immunol. 2015 Nov;76(11):819-22. doi: 10.1016/j.humimm.2015.09.042. Epub 2015 Sep 30.

Abstract

FCGR2A and CCL2 gene variants are important in dengue pathogenesis and were investigated in 122 dengue patients (DENs) [89 dengue fever (DF) and 33 dengue hemorrhagic fever (DHF)] and 107 healthy controls (HCs) to find out their association with severity of dengue. Genotype frequencies of FCGR2A p.R131H and CCL2 c.-2518 A > G polymorphisms were not different between DF, DHF and HC. Significantly higher frequency of R/R genotype of FCGR2A p.R131H was observed in DEN cases with thrombocytopenia (TP) while the G/G genotype of CCL2 c.-2518 A > G was observed only in DEN cases with TP (p < 0.005). These results suggest that FCGR2A and CCL2 gene variants were associated with the risk of TP in dengue infections.

Keywords: CCL2; Dengue; Dengue fever; Dengue hemorrhagic fever; FCGR2A; Gene polymorphisms; Thrombocytopenia.

MeSH terms

  • Adult
  • Alleles
  • Case-Control Studies
  • Chemokine CCL2 / genetics*
  • Dengue / complications*
  • Dengue / genetics
  • Dengue Virus*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Receptors, IgG / genetics*
  • Severe Dengue / complications
  • Severe Dengue / genetics
  • Thrombocytopenia / etiology*
  • Young Adult

Substances

  • Chemokine CCL2
  • FCGR2A protein, human
  • Receptors, IgG