A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children

Anaesthesia. 2016 Jan;71(1):50-7. doi: 10.1111/anae.13230. Epub 2015 Oct 7.

Abstract

Emergence delirium is a common problem in children recovering from general anaesthesia. We performed a study comparing emergence characteristics in 100 patients who were randomly allocated to receive either 0.3 μg.kg(-1) dexmedetomidine, 1 mg.kg(-1) propofol or saline 0.9% and undergoing infra-umbilical surgery. The Pediatric Anesthesia Emergence Delirium scale was used to grade emergence delirium. Emergence delirium occurred in 9.4% of children in the dexmedetomidine group compared with 13.9% in the propofol group and 40.6% in the control group (p = 0.004). In the dexmedetomidine group, sedation occurred in 62.5% of children at 10 min after transfer to the recovery area, compared with 44.4% in the propofol group and 12.5% in the control group (p = 0.010). We conclude that dexmedetomidine significantly reduced the incidence of emergence delirium but this was at the expense of a greater incidence of sedation in the recovery period.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Anesthetics, Inhalation / adverse effects*
  • Child
  • Child, Preschool
  • Delirium / prevention & control*
  • Desflurane
  • Dexmedetomidine / therapeutic use*
  • Female
  • Humans
  • Isoflurane / adverse effects
  • Isoflurane / analogs & derivatives*
  • Male
  • Propofol / therapeutic use*

Substances

  • Anesthetics, Inhalation
  • Dexmedetomidine
  • Desflurane
  • Isoflurane
  • Propofol