Interleukin-22 inhibits tazarotene-induced gene 3 expression in HaCaT cells via MAPK-ERK1/2 and JAK2/STAT3 signaling

J Dermatol Sci. 2015 Nov;80(2):162-4. doi: 10.1016/j.jdermsci.2015.09.006. Epub 2015 Sep 26.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / drug effects
  • Cell Line
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation
  • Humans
  • Interleukin-22
  • Interleukins / pharmacology*
  • Janus Kinase 2 / antagonists & inhibitors
  • Janus Kinase 2 / metabolism*
  • Keratinocytes / drug effects*
  • Keratinocytes / enzymology
  • Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors
  • Mitogen-Activated Protein Kinase 1 / metabolism*
  • Mitogen-Activated Protein Kinase 3 / antagonists & inhibitors
  • Mitogen-Activated Protein Kinase 3 / metabolism*
  • Protein Kinase Inhibitors / pharmacology
  • Receptors, Retinoic Acid / genetics
  • Receptors, Retinoic Acid / metabolism*
  • STAT3 Transcription Factor / metabolism*
  • Signal Transduction / drug effects*

Substances

  • Interleukins
  • PLAAT4 protein, human
  • Protein Kinase Inhibitors
  • Receptors, Retinoic Acid
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • JAK2 protein, human
  • Janus Kinase 2
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3