Synchronous pituitary adenoma and pituicytoma

Marian C Neidert; Henning Leske; Jan-Karl Burkhardt; Spyros S Kollias; David Capper; Daniel Schrimpf; Luca Regli; Elisabeth J Rushing

doi:10.1016/j.humpath.2015.08.017

Synchronous pituitary adenoma and pituicytoma

Hum Pathol. 2016 Jan;47(1):138-43. doi: 10.1016/j.humpath.2015.08.017. Epub 2015 Sep 16.

Authors

Marian C Neidert¹, Henning Leske², Jan-Karl Burkhardt¹, Spyros S Kollias³, David Capper⁴, Daniel Schrimpf⁴, Luca Regli¹, Elisabeth J Rushing⁵

Affiliations

¹ Department of Neurosurgery, University Hospital Zurich, CH-8091 Zurich, Switzerland.
² Department of Neuropathology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
³ Department of Neuroradiology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
⁴ Department of Neuropathology, University Hospital Heidelberg and German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), DE-69120 Heidelberg, Germany.
⁵ Department of Neuropathology, University Hospital Zurich, CH-8091 Zurich, Switzerland. Electronic address: ElisabethJane.Rushing@usz.ch.

PMID: 26476569
DOI: 10.1016/j.humpath.2015.08.017

Abstract

Pituicytoma is a rare benign neoplasm arising in the sellar region, usually found in the posterior lobe and/or pituitary stalk. Here, we report the case of a 67-year-old woman who presented with bitemporal hemianopsia and visual impairment accompanied by mildly elevated prolactin. Pathologic and molecular examination of the tissue removed transsphenoidally revealed 2 distinct tumors: pituitary adenoma and pituicytoma. To the best of our knowledge, histologically proven pituicytoma and pituitary adenoma have never been reported together.

Keywords: MRI; Pituicyte; Pituicytoma; Pituitary adenoma; TTF1.

Publication types

Case Reports

MeSH terms

Adenoma / blood
Adenoma / complications
Adenoma / genetics
Adenoma / pathology*
Adenoma / surgery
Aged
Biomarkers, Tumor / blood
Biomarkers, Tumor / genetics
Biopsy
DNA Methylation
Endoscopy
Female
Hemianopsia / etiology
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Neoplasms, Multiple Primary / blood
Neoplasms, Multiple Primary / complications
Neoplasms, Multiple Primary / genetics
Neoplasms, Multiple Primary / pathology*
Neoplasms, Multiple Primary / surgery
Pituitary Neoplasms / blood
Pituitary Neoplasms / complications
Pituitary Neoplasms / genetics
Pituitary Neoplasms / pathology*
Pituitary Neoplasms / surgery
Prolactin / blood
Visual Fields

Substances

Biomarkers, Tumor
Prolactin