The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population

Yadong Wang; Haiyan Yang; Huiyan Gao; Haiyu Wang

doi:10.1007/s13277-015-3321-6

The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population

Tumour Biol. 2015 Dec;36(12):9153-8. doi: 10.1007/s13277-015-3321-6. Epub 2015 Nov 4.

Authors

Yadong Wang¹, Haiyan Yang², Huiyan Gao³, Haiyu Wang³

Affiliations

¹ Department of Toxicology, Henan Center for Disease Control and Prevention, No. 105 of South Nongye Road, Zhengzhou, 450016, China. wangyd76@yahoo.com.
² Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, 450052, China.
³ Department of Toxicology, Henan Center for Disease Control and Prevention, No. 105 of South Nongye Road, Zhengzhou, 450016, China.

PMID: 26537580
DOI: 10.1007/s13277-015-3321-6

Abstract

With great interest, we read the recent article entitled "Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies" published online in Tumor Biology, 2014, 35: 1695-1701. This article suggests that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism was significantly associated with breast cancer risk in Chinese population. The result is encouraging. Nevertheless, three key issues in this meta-analysis are worth noticing.

Keywords: Breast cancer; Chinese; MTHFR; Meta-analysis; Polymorphism; Risk.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Asian People
Breast Neoplasms / genetics*
Breast Neoplasms / pathology
China
Female
Genetic Association Studies*
Genetic Predisposition to Disease
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymorphism, Single Nucleotide
Risk Factors

Substances

MTHFR protein, human
Methylenetetrahydrofolate Reductase (NADPH2)