Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents

Eur Arch Psychiatry Clin Neurosci. 2016 Dec;266(8):771-773. doi: 10.1007/s00406-015-0664-3. Epub 2015 Nov 30.

Abstract

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.

Keywords: Conduct disorder; DβH; Genetic; Psychopathy.

MeSH terms

  • Adolescent
  • Analysis of Variance
  • Antisocial Personality Disorder / genetics*
  • Conduct Disorder / genetics*
  • Dopamine beta-Hydroxylase / genetics*
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Juvenile Delinquency / psychology*
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide / genetics*
  • Russia

Substances

  • Dopamine beta-Hydroxylase