Scientific Significance of Clinically Insignificant FcγRIIIa-V158F Polymorphism

Clin Cancer Res. 2016 Feb 15;22(4):787-9. doi: 10.1158/1078-0432.CCR-15-2777. Epub 2015 Dec 18.

Abstract

Kenkre and colleagues report the absence of correlation between FcγRIIIa-V158F polymorphism and rituximab response in follicular lymphoma patients, a result which is in contrast with prior studies. This discrepancy recalls that many other factors (from the host and from the tumor) may influence the efficacy of rituximab in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Murine-Derived*
  • Humans
  • Lymphoma, Follicular / drug therapy
  • Polymorphism, Genetic
  • Receptors, IgG / genetics*
  • Rituximab

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Receptors, IgG
  • Rituximab