Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han

Xijia Xu; Shiping Xie; Xiaomeng Shi; Jie Lv; Xiaowei Tang; Xiaolan Wang; Shuiping Lu; Mingzhong Wang; Xiaobing Zhang; Jing Sun; Hui Yao

doi:10.1371/journal.pone.0145347

Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han

PLoS One. 2015 Dec 21;10(12):e0145347. doi: 10.1371/journal.pone.0145347. eCollection 2015.

Authors

Xijia Xu^{1

2}, Shiping Xie^{1

2}, Xiaomeng Shi¹, Jie Lv³, Xiaowei Tang⁴, Xiaolan Wang¹, Shuiping Lu¹, Mingzhong Wang³, Xiaobing Zhang⁴, Jing Sun¹, Hui Yao¹

Affiliations

¹ Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
² Nanjing Brain Hospital, Nanjing University Medical School, Nanjing, 210093, China.
³ Department of Psychiatry, Nanjing Qinglongshan Mental Hospital, Nanjing, 211123, China.
⁴ Department of Psychiatry, Affiliated Wutaishan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, China.

Abstract

Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from several other degenerative diseases. However, whether it is present in the treatment-resistant schizophrenia patients remains unknown. Genotyping 386 patients suffering from treatment-resistant schizophrenia using the method of Repeat-Primed PCR, we reported here that no HRE was detected in the patients of Chinese Han.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Antipsychotic Agents / therapeutic use
Asian People / genetics
C9orf72 Protein
Case-Control Studies
DNA Repeat Expansion*
Female
Humans
Male
Middle Aged
Proteins / genetics*
Schizophrenia / drug therapy
Schizophrenia / genetics*
Young Adult

Substances

Antipsychotic Agents
C9orf72 Protein
C9orf72 protein, human
Proteins

Grants and funding

This work was funded by Nanjing Medical Science and Technique Development Foundation, Nanjing Commission of Health and Family Planning (grant numbers: QRX11121, ZKX08034; http://www.njjsw.gov.cn/; recipient: XX); Jiangsu Provincial Commission of Health and Family Planning (grant number: H200875; http://www.jswst.gov.cn; recipient: XX); National Health and Family Planning Commission of the People’s Republic of China (grant number: State Key Clinical Specialty [Psychiatry, 2011-873]; http://www.nhfpc.gov.cn/; recipients: XX SX); and Jiangsu Provincial Commission of Health and Family Planning (grant number: Provincial Medical Key Discipline [Psychiatry, 2011-12]; http://www.jswst.gov.cn; recipients: XX SX). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.