Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

Christopher J Ward; Madhulika Sharma

doi:10.1016/j.cub.2015.09.061

Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

Curr Biol. 2015 Dec 21;25(24):R1168-70. doi: 10.1016/j.cub.2015.09.061.

Authors

Christopher J Ward¹, Madhulika Sharma²

Affiliations

¹ Department of Internal Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66103, USA. Electronic address: cward6@kumc.edu.
² Department of Internal Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66103, USA.

Abstract

Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.

MeSH terms

Animals
Caenorhabditis elegans / genetics*
Caenorhabditis elegans Proteins / genetics*
Caenorhabditis elegans Proteins / metabolism
Female
Humans
Male
Polycystic Kidney Diseases / genetics
Sexual Behavior, Animal*
TRPP Cation Channels / genetics*
TRPP Cation Channels / metabolism

Substances

Caenorhabditis elegans Proteins
LOV-1 protein, C elegans
PKD-2 protein, C elegans
TRPP Cation Channels

Grants and funding

R01 DK108433/DK/NIDDK NIH HHS/United States