The oncogene ETS1 is distant from the chromosome 11 breakpoint in leukaemic cells with the t(11;19)(q23;p13)

M A Kennedy; C M Morris; P H Fitzgerald

doi:10.1016/0145-2126(89)90167-7

The oncogene ETS1 is distant from the chromosome 11 breakpoint in leukaemic cells with the t(11;19)(q23;p13)

Leuk Res. 1989;13(6):459-63. doi: 10.1016/0145-2126(89)90167-7.

Authors

M A Kennedy¹, C M Morris, P H Fitzgerald

Affiliation

¹ Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.

PMID: 2671514
DOI: 10.1016/0145-2126(89)90167-7

Abstract

Field inversion gel electrophoresis of DNA from a leukemic clone characterized by the t(11;19)(q23;p13) allowed us to exclude any genomic rearrangement within more than 900 kb of DNA encompassing ETS1 on chromosome 11. Although ETS1 was moved to the derivative chromosome 19 as a result of the t(11;19), we conclude that this oncogene is not close to the chromosome 11 breakpoint and is unlikely to be involved in this leukaemia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Blotting, Southern
Chromosomes, Human, Pair 11 / ultrastructure*
Chromosomes, Human, Pair 19 / ultrastructure*
DNA, Neoplasm / genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Male
Oncogenes*
Proto-Oncogene Protein c-ets-1
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-ets
Restriction Mapping
Transcription Factors*
Translocation, Genetic

Substances

DNA, Neoplasm
ETS1 protein, human
Proto-Oncogene Protein c-ets-1
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ets
Transcription Factors