Relationship between Alzheimer's disease GWAS-linked top hits and risk of Parkinson's disease with or without cognitive decline: a Chinese population-based study

Ya-qin Wang; Bei-sha Tang; Yang Yang; Yi-ting Cui; Ji-feng Kang; Zhen-hua Liu; Kai Li; Qi-ying Sun; Qian Xu; Xin-xiang Yan; Ji-feng Guo

doi:10.1016/j.neurobiolaging.2015.11.024

Relationship between Alzheimer's disease GWAS-linked top hits and risk of Parkinson's disease with or without cognitive decline: a Chinese population-based study

Neurobiol Aging. 2016 Mar:39:217.e9-11. doi: 10.1016/j.neurobiolaging.2015.11.024. Epub 2015 Dec 7.

Authors

Ya-qin Wang¹, Bei-sha Tang², Yang Yang¹, Yi-ting Cui¹, Ji-feng Kang¹, Zhen-hua Liu¹, Kai Li¹, Qi-ying Sun³, Qian Xu³, Xin-xiang Yan³, Ji-feng Guo⁴

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
² Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha, Hunan, People's Republic of China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China.
³ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China.
⁴ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha, Hunan, People's Republic of China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, People's Republic of China. Electronic address: guojifeng2003@163.com.

PMID: 26724962
DOI: 10.1016/j.neurobiolaging.2015.11.024

Abstract

Alzheimer's disease (AD), Parkinson's disease (PD), and cognitive impairment in PD have overlapping clinical and pathological features. To examine whether there is a genetic link for these diseases, we performed a case-control study in Chinese population to evaluate the association of AD genome-wide association studies top hits with both PD and cognitive function in PD, investigating 13 single-nucleotide polymorphisms in 9 genes (BIN1, CLU, ABCA7, CR1, PICALM, MS4A6A, CD33, MS4A4E, and CD2AP). A total of 454 controls and 442 PD patients were genotyped, including 75 mild cognitive impairment and 99 dementia. As a result, no significant association of the AD-susceptibility loci was identified in PD cases, PD-dementia, or PD-mild cognitive impairment. Our findings imply that the 13 single-nucleotide polymorphisms from AD genome-wide association studies may not play major role in the genetic predisposition with PD and cognitive function in PD in a Chinese population.

Keywords: Alzheimer's disease; Cognitive decline; Genetic susceptibility; Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease / genetics*
Asian People / genetics
Case-Control Studies
Cognition*
Cognitive Dysfunction / etiology
Cognitive Dysfunction / genetics*
Dementia / etiology
Dementia / genetics*
Female
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study*
Humans
Male
Middle Aged
Parkinson Disease / complications
Parkinson Disease / genetics*
Parkinson Disease / psychology
Polymorphism, Single Nucleotide
Risk