Abstract
A fusion between the EML4 (echinoderm microtubule-associated protein-like) and ALK (anaplastic lymphoma kinase) genes was identified in non-small cell lung cancer (NSCLC) in 2007 and there has been rapid progress in applying this knowledge to the benefit of patients. However, we have a poor understanding of EML4 and ALK biology and there are many challenges to devising the optimal strategy for treating EML4-ALK NSCLC patients. In this review, we describe the biology of EML4 and ALK, explain the main features of EML4-ALK fusion proteins and outline the therapies that target EML4-ALK. In particular, we highlight the recent advances in our understanding of the structures of EML proteins, describe the molecular mechanisms of resistance to ALK inhibitors and assess current thinking about combinations of ALK drugs with inhibitors that target other kinases or Hsp90.
Keywords:
Fusion; Kinase; Lung cancer; Oncogene; Structural biology.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Anaplastic Lymphoma Kinase
-
Animals
-
Carcinoma, Non-Small-Cell Lung / drug therapy
-
Carcinoma, Non-Small-Cell Lung / genetics*
-
Carcinoma, Non-Small-Cell Lung / metabolism
-
Carcinoma, Non-Small-Cell Lung / pathology
-
Cell Cycle Proteins / analysis
-
Cell Cycle Proteins / genetics*
-
Cell Cycle Proteins / metabolism
-
HSP90 Heat-Shock Proteins / antagonists & inhibitors
-
Humans
-
Lung / metabolism
-
Lung / pathology*
-
Lung Neoplasms / genetics*
-
Lung Neoplasms / metabolism
-
Lung Neoplasms / pathology
-
Microtubule-Associated Proteins / analysis
-
Microtubule-Associated Proteins / genetics*
-
Microtubule-Associated Proteins / metabolism
-
Models, Molecular
-
Molecular Targeted Therapy
-
Oncogene Proteins, Fusion / analysis
-
Oncogene Proteins, Fusion / genetics*
-
Oncogene Proteins, Fusion / metabolism
-
Protein Conformation
-
Protein Kinase Inhibitors / pharmacology
-
Protein Kinase Inhibitors / therapeutic use
-
Receptor Protein-Tyrosine Kinases / analysis
-
Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
-
Receptor Protein-Tyrosine Kinases / genetics*
-
Receptor Protein-Tyrosine Kinases / metabolism
-
Serine Endopeptidases / analysis
-
Serine Endopeptidases / genetics*
-
Serine Endopeptidases / metabolism
Substances
-
Cell Cycle Proteins
-
EML4-ALK fusion protein, human
-
HSP90 Heat-Shock Proteins
-
Microtubule-Associated Proteins
-
Oncogene Proteins, Fusion
-
Protein Kinase Inhibitors
-
ALK protein, human
-
Anaplastic Lymphoma Kinase
-
Receptor Protein-Tyrosine Kinases
-
EML4 protein, human
-
Serine Endopeptidases