Abstract
Aim:
To investigate the correlation between DKK1 polymorphisms with bone phenotypes and response to alendronate treatment.
Materials & methods:
Five tag single nucleotide polymorphisms of DKK1 were analyzed in 639 Chinese postmenopausal women with osteoporosis or osteopenia. Bone mineral density (BMD), β-CTX and ALP were measured before and after alendronate treatment.
Results:
Genotypes at rs1896367, rs1528877 and rs2241529 correlated to baseline BMD (p < 0.05). rs1528877 and rs2241529 polymorphisms correlated to baseline β-CTX levels (p < 0.05). rs2241529 polymorphisms of DKK1 had a small influence on the skeletal response to alendronate treatment (p < 0.05).
Conclusion:
DKK1 polymorphisms may correlate to baseline BMD and serum β-CTX levels, but present a weak effect on the response to alendronate.
Keywords:
DKK1 gene polymorphisms; alendronate; bone mineral density; osteoporosis; response to treatment.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Alendronate / therapeutic use*
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Alkaline Phosphatase / blood
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Asian People
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Biomarkers / blood
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Bone Density / drug effects*
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Bone Density Conservation Agents / therapeutic use*
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Bone Diseases, Metabolic / drug therapy
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Bone Diseases, Metabolic / genetics
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Bone Diseases, Metabolic / physiopathology
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Bone Remodeling / drug effects*
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Collagen Type I / blood
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Creatinine / blood
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Genetic Association Studies
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Humans
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Intercellular Signaling Peptides and Proteins / genetics*
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Osteoporosis, Postmenopausal / drug therapy
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Osteoporosis, Postmenopausal / genetics
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Osteoporosis, Postmenopausal / physiopathology
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Peptides / blood
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Polymorphism, Single Nucleotide
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Prospective Studies
Substances
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Biomarkers
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Bone Density Conservation Agents
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Collagen Type I
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DKK1 protein, human
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Intercellular Signaling Peptides and Proteins
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Peptides
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collagen type I trimeric cross-linked peptide
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Creatinine
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Alanine Transaminase
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Alkaline Phosphatase
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Alendronate